研究员

龙 勉

1980.09-1984.07  上海交通大学动力机械工程系 科学学士

1989.03-1990.03  日本Gunma大学 联合培养博士

1990.07      重庆大学生物工程研究中心 工学博士(中日联培)

1995.03      重庆大学生物工程研究(学)院 教授

1996.06-1999.08  美国Georgia Institute of Technology 高访学者

2000.07      中国科学院力学研究所 研究员、博士生导师


简 历
主要论著

1. Gong Y.X., Zhang Y., Feng S.L., Liu X.F., Lü S.Q., and Long M. 2017. Dynamic contributions of P- and E-selectins to β2-integrin-induced neutrophil transmigration. FASEB J., 31(1): 212-223.

2. Zhang C., Zhou L.W., Zhang F., Lü D.Y., Li N., Zheng L., Xu Y.H., Li Z., Sun S.J., and Long M. 2017. Mechanical remodeling of normally sized mammalian cells under a gravity vector. FASEB J., 31(2): 802-813.

3. Du Y., Li N., Yang Y., Luo C.H., Gong Y.X., Tong C.F., Gao Y.X., Lü S.Q., and Long M. 2017. Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip. Lab on a Chip (Inner Cover story), 17: 782-794.

4. Qi J.Y., Wu B.B., Feng S.L., Lü S.Q., Guan C.M., Zhang X., Qiu D.L., Hu Y.C., Zhou Y.H., Li C.Y., Long M., and Jiao Y.L. 2017. Mechanical regulation of organ asymmetry in leaves. Nature Plants, 3: 724-733.

5. Zhang X., Li L.D., Li N., Shu X.Y., Zhou L.W., Lü S.Q., Chen S.B., Mao D.B., and Long M. 2018. Salt bridge interactions within the β2 integrin α7 helix mediate force-induced binding and shear resistance ability. FEBS. J., 285: 261-274.

6. Tong C.F., Zhang Y., Lü S.Q., Li N., Gong Y.X., Yang H., Feng S.L., Du Y., Huang D.D., and Long M. 2018. Binding of intercellular adhesion molecule 1 to β2-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium. Am. J. Physiol.-Cell Physiol., 315: C409-C421.

7. Lü D.Y., Sun S.J., Zhang F., Luo C.H., Zheng L., Wu Y., Li N., Zhang C., Wang C.Z., Chen Q., and Long M. 2019. Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite. FASEB J., 33: 4273-4286.

8. Peng S., Chen S.B., Li L.D., Tong C.F., Li N., Lü S.Q., and Long M. 2019. Impact of real-time shedding on binding kinetics of membrane-remaining L-selectin to PSGL-1. Am. J. Physiol.-Cell Physiol., 316: C678-C689.

9. Xu Y.H., Huang D.D., Lü S.Q., Zhang Y., and Long M. 2019. Mechanical features of endothelium regulates cell adhesive molecule-induced calcium response in neutrophils. APL Bioengi., 3(1): 016104.

10. Wang J.W., Wu Y., Zhang X., Zhang F., Lü D.Y., Shangguan B., Gao Y.X., and Long M. 2019. Flow-enhanced priming of hESCs through H2B acetylation and chromatin decondensation. Stem Cell Res. Ther., 10: 349.

11. Wu X.S., Hu J.R., Li G.Q., Li Yan, Li Yang, Zhang J., Wang F., Li A., Hu L., Fan Z.P., Lü S.Q., Ding G., Zhang C.M., Wang J.S., Long M., and Wang S.L. 2019. Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway. EMBO J., e102374.

12. Zheng L., Lü D.Y., Zhang F., Xing M., Wang X.Y., Jia X.H., Shu X.Y., Li P.W., Lü S.Q., Chang J., and Long M. 2020. Regulation of hepatic differentiation of human embryonic stem cells by calcium silicate extracts for liver injury repairing. Appl. Mater. Today, 20: 100730.

13. Elad D., Zaretsky U., Kuperman T., Gavriel M., Long M., Jaffa A., and Grisaru D. 2020. Tissue engineered endometrial barrier exposed to peristaltic flow shear stresses. APL Bioengi., 4: 026107.

14. Zhou L.W., Du F., Feng S.L., Hu J.R., Lü S.Q., Long M., and Jiao Y.L. 2020. Epidermal restriction confers robustness to organ shapes. J. Integr. Plant Biol., 62(12): 1853-1867.

15. Zhao F., Du D., Oliveri H., Zhou L.W., Ali O., Chen W.Q., Feng S.L., Wang Q.Q., Lü S.Q., Long M., Schneider R., Sampathkumar A., Godin C., Traas J., and Jiao Y.L. 2020. Microtubule-mediated wall anisotropy contributes to leaf blade flattening. Curr. Biol., 30: 3972-3985.

16. Zhang M.K., Chen S.B., Hu J.R., Ding Q.H., Li L.D., Lü S.Q., and Long M. 2021. Mapping morphological identifiers for distinct conformations via protein translocation current in nanopore. Nanoscale, 13: 6053-6065.

17. Huang D.D., Ding Q.H., Chen S.B., Lü S.Q., Zhang Y., and Long M. 2021. E-selectin knockdown promotes transendothelial migration of neutrophils by reducing endothelial junction integrity. FASEB J., 35: e21521.

18. Xiong Y.Y., Wu B.B., Du F., Guo X.L., Tian C.H., Hu J.R., Lü S.Q., Long M., Zhang L., Wang Y. and Jiao Y.L. 2021. A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy. Mol. Plant, 14(6): 949-962.

19. Luo C.H., Lü D.Y., Zheng L., Zhang F., Zhang X., Lü S.Q., Zhang C., Jia X.H., Li Z., and Long M. 2021. Hepatic differentiation of human embryonic stem cells on coupled substrate stiffness and microtopography. Biomaterials Sci., 9: 3776-3790.

20. Lyu X.C., Wang J., Zhu Y., Li L.L., Huang S.R., Peng S., Xue B.X., Huang C., Liao R.Y., Wang S.Q., Long M., Wohland T., Chua B.T., Sun Y.J., Li P.L., Chen F.J., and Li P. 2021. A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. Dev. Cell, 56: 1-15.

21. Zhou L.W., Feng S.L., Li L., Lü S.Q., Zhang Y., and Long M. 2021. Two complementary signaling pathways depict eukaryotic chemotaxis: A mechanochemical coupling model. Front. Cell Dev. Biol., 9: 786254.

22. Qiao C.X., Lv M., Li X.Y., Lang X.L., Lv S.Q., Long M, Li Y., Geng S.S., Lin Z., Shen B.F., Feng J.N. 2021. A novel human antibody HF against erbB2/HER2 obtained by computer-guided antibody design method. Engineering, 007: 1566-1576.

23. Li L.D., Ding Q.H., Zhou J., Wu Y., Zhang M.K., GuoX.M., Long M., and Lü S.Q. 2022. Distinct binding kinetics of E-, P- and L-selectin to CD44. FEBS J., 289: 2877-2894.

24. Li N., Zhang X.Y., Zhou J., Li W., Shu X.Y., Wu Y., Long M., 2022. Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer. Adv Drug Deliver Rev. 188: 114448.


获奖及荣誉

2000年:入选中科院“百人计划”

2002年:获国家杰出青年基金

2004年:入选“新世纪百千万人才工程国家级人选”

2011-2015 年:973项目首席科学家

2015年:入选美国医学与生物工程院(AIMBE)会士

2017年:入选国际医学与生物工程科学院(IAMBE)会士


承担科研项目情况
研究方向

1、分子生物力学与力学-化学耦合

定量认识特定生理力学/物理环境下,生物大分子相互作用与组装动力学对免疫识别、细胞粘附与聚集、胞内信号转导等生物学过程的影响。

发展可定量评价抗体药物设计合理性、及其与细胞表面靶标作用亲和性的模拟与实验方法,建立抗体药物设计与评价的生物力学平台。

2、细胞生物力学与力学-生物学耦合

定量阐释力学刺激下细胞-亚细胞层次生物学响应的生物力学机制,重点关注基质力学性质与拓扑结构对细胞分化的调控规律。

发展力谱-荧光谱耦合检测平台,在重现活细胞复杂生理力学环境下,构建活细胞动态力学图谱,深化认识细胞力学-生物学耦合的内在分子机制。

3、工程化组织及器官构建

构建模拟特定生理力学/物理微环境的体外微组织-微器官模型,定量阐释生理力学微环境下跨尺度的力学-生物学耦合规律。

整合工程化组织构建技术与生理组织特化功能机理研究,发展器官特异性芯片,面向组织/器官构建与药物筛选。

4、空间生物力学与工程

定量阐明(微)重力下细胞的力学-生物学耦合规律,发展空间细胞生物学研究和空间生物技术的生物力学新概念、新方法和新装置。